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KMID : 1161420100130020427
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Journal of Medicinal Food
2010 Volume.13 No. 2 p.427 ~ p.438
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Long-Term Treatment with Shengmai San-Derived Herbal Supplement (Wei Kang Su) Enhances Antioxidant Response in Various Tissues of Rats with Protection Against Carbon Tetrachloride Hepatotoxicity
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Leong Pou Kuan
Chen Na
Chiu Po Yee
Leung Hoi Yan
Ma Chung Wah
Tang Qing Tao
Ko Kam Ming
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Abstract
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Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.
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KEYWORD
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carbon tetrachloride, glutathione, heat shock response, mitochondria, reactive oxygen metabolites
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